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KMID : 0104920170260010025
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Journal of Hawhwa Medicine
2017 Volume.26 No. 1 p.25 ~ p.32
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The Effects of Hyangsayangwi-tang (Xiangshayangwei-tang) Intravenous Herbal Acupuncture on Chemotherapy-induced Emesis and Gastric Motility in Rats
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Choi Kang-Min
Lee Chan
Yim Yun-Kyoung
Lee Hyun-Jin
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Abstract
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Objectives : The purpose of this study is to investigate the effects of Hyangsayangwi-tang (Xiangshayangwei-tang) intravenous herbal acupuncture (HYT-IVHA) on emesis and gastric hypomotility induced by chemotherapy in rats.
Methods : The experimental animals were randomly allocated into six groups (normal, cisplatin, saline, HYT-1, HYT-2, HYT-3), and each group included five rats. The rats in the normal group did not receive any treatment. Those in the cisplatin group had no additional treatment after intraperitoneal injection of cisplatin (7 ㎎/㎏). Those in the saline group were injected with saline 0.4 ㎖ via the tail vein after the injection of cisplatin. Those in the HYT-1 group, HYT-2 group, HYT-3 group were injected with 0.4 ㎖ of Hyangsayangwi-tang (Xiangshayangwei-tang) intravenous herbal acupuncture solution (HYT-IVHAS) via tail vein after the injection of cisplatin, and the concentrations were 0.199 g/kg, 0.066 g/kg, 0.022 g/kg respectively. Then we measured body weight, food intake and kaolin consumption before and at 12h, 24h and 36h after the injection of cisplatin. The remaining amount of food within the rat’s stomach was also measured at 36h after cisplatin injection.
Results : Kaolin consumption was significantly increased in the cisplatin group compared to the normal group, while significantly reduced in HYT-1, HYT-2, HYT-3 groups compared to the cisplatin group. The remaining amount of food in stomach was significantly increased in the cisplatin group and HYT-1 group compared to the normal group, but significantly reduced in the HYT-3 group compared to the cisplatin group.
Conclusions : HYT-IVHA has an therapeutic effect on chemotherapy-induced emesis and gastric hypomotility.
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KEYWORD
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Hyangsayangwi-tang, Xiangshayangwei-tang, Intravenous herbal acupuncture, Cisplatin, Chemotherapy-induced emesis, Gastric motility
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